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Garrin is a 7-year-old boy with cystic fibrosis. The disease is caused by a genetic defect on chromosome 7. As a result, there is a defective production of protein chloride channels in epithelial cell membranes. One effect of the disease is the production of thick mucous that accumulates in Garrin’s bronchial passages. As a result, he attends a physiotherapy clinic regularly for chest percussion treatments to loosen the respiratory mucous.
Garrin’s disease is hereditary. What does it mean to have a genetic defect on chromosome 7 in terms of DNA, genes, and chromosomes?In cystic fibrosis, cellular chloride channels are defective. Anatomically, what type of channel is this, and what is its importance in cell function?
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